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This glutathione depletion impairs cellular antioxidant capacity, leaving cells vulnerable to ROS accumulation

Increased ATP/ADP ratio induces the closure of ATP-sensitive potassium (K ATP ) channels, leading to membrane depolarization followed by activation of voltage-gated Ca 2+ channels (VGCC) and Ca 2+ influx

Lagan M, Piticchio T, Alibrandi A, Le Moli R, Pallotti F, Campenn A et al (2025) Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimotos Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet